[Usefulness of self-expanding biodegradable prosthesis in the treatment of refractory benign stenosis: a case series study]. / Utilidad de las prótesis autoexpandibles biodegradables en el tratamiento de estenosis benignas refractarias. Estudio de una serie de casos.

BACKGROUND: The use of self-expanding biodegradable prosthesis treatment of refractory benign stenosis is still undefined. OBJECTIVE: To determine the utility and safety of biodegradable polydioxanone prostheses as treatment of gastrointestinal tract refractory benign strictures. METHODS: Consecutive patients diagnosed with refractory benign stricture of gastrointestinal tract following Kochman's criteria were included. The type of stenosis were anastomotic (n = 5), peptic (n = 1), post-radiotherapy (n = 1) and they were located in proximal esophagus-hypofarynge (n = 2), esophagus medium (n = 1), distal esophagus (n = 2) and rectum (n = 2). The prosthesis was placed under endoscopic and fluoroscopic control under conscious sedation with propofol. RESULTS: Seven patients (8 prosthesis) were included. Mean patient age was 49 years-old (range: 37-70). Insertion prosthesis was successful in all cases. Distal migration of prosthesis was observed in both rectal stenosis and was the indication of a second prosthesis placement in one case. At the end of follow-up (median follow-up 30 weeks for esophageal stricture, 33 weeks for rectal stricture) 5 patients remained asymptomatic. Eighty per cent of patients with esophageal stenosis showed partial and transient re-stenosis due to hyperplastic reaction during the degradation of the prosthesis, with transient dysphagia in two patients resolved medically. Complete prosthesis degradation was confirmed by endoscopy in all cases. CONCLUSIONS: The use of self-expanding biodegradable polydioxanone prosthesis is a safe and utile therapeutic option for refractory benign gastrointestinal stenosis.

Dosis reducidas de terapia fotodinámica con Verteporfin en el tratamiento de la coriorretinopatía central serosa crónica / Low dose photodynamic therapy for chronic central serous chorioretinopathy

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[Intravitreal injection of bevacizumab (Avastin) for retinal angiomatous proliferation]. / Inyección intravítrea de bevacizumab (Avastin) para proliferación angiomatosa retiniana.

CLINICAL CASE: An 81-year-old man presented with stage 2 retinal angiomatous proliferation (RAP) as identified by fluorescein angiography and optical coherence tomography (OCT), and was shown to have a visual acuity (VA) of 20/40. One week after an intravitreal injection of bevacizumab (1.25 mg) the VA improved to 20/25, and the OCT showed a reduction of both intraretinal edema and pigment epithelium detachment. Three months after the injection, no ocular complications were observed, VA was 20/20 and the OCT showed an almost normal macular contour. DISCUSSION: Intravitreal injection of bevacizumab may provide another treatment option for patients with RAP.

Inyección intravítrea de bevacizumab (Avastin(R)) para proliferación angiomatosa retiniana / Intravitreal injection of Bevacizumab (Avastin(R)) for retinal angiomatous proliferation

Caso clínico: Paciente varón de 81 años con proliferación angiomatosa retiniana (PAR) en estadio 2 identificado mediante angiografía fluoresceínica y tomografía de coherencia óptica (OCT) y con agudeza visual (AV) de 20/40. Una semana tras la inyección intravítrea de bevacizumab (1,25 mg), la AV mejoró a 20/25, y la OCT demostró reducción del edema intrarretiniano y del desprendimiento del epitelio pigmentario. Tres meses tras la inyección no se detectó ninguna complicación a nivel ocular, la AV era de 20/20 y la OCT mostraba un contorno macular prácticamente normal. Discusión: La inyección intravítrea de bevacizumab puede aportar una nueva opción terapéutica para los pacientes con PAR

Clinical case: An 81-year-old man presented with stage 2 retinal angiomatous proliferation (RAP) as identified by fluorescein angiography and optical coherence tomography (OCT), and was shown to have a visual acuity (VA) of 20/40. One week after an intravitreal injection of bevacizumab (1.25 mg) the VA improved to 20/25, and the OCT showed a reduction of both intraretinal edema and pigment epithelium detachment. Three months after the injection, no ocular complications were observed, VA was 20/20 and the OCT showed an almost normal macular contour. Discussion: Intravitreal injection of bevacizumab may provide another treatment option for patients with RAP

¿Debemos recetar antioxidantes en pacientes con DMAE? / Should we prescribe antioxidant drugs in ARMD patients?

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Magnetic field influence on electrical properties of human blood measured by impedance spectroscopy.

The impedance spectroscopy technique (IST) was used for studying the effect of a 0.5 T magnetic field on the electrical properties of whole human blood. A Solartron SI 1260 spectrometer was used to measure the impedance spectra of magnetic field exposed blood samples compared to non-exposed samples. An equivalent electrical circuit model, consisting in a resistance Rs in series with a parallel circuit formed by a constant phase element (CPE) and another resistance Rp, is proposed to fit the data in both cases. The experiment used 3 ml human blood samples from 160 healthy donors. A Wilcoxon matched pairs statistical test was applied to the data. The data analysis seems to show a statistically significant increase of the values of resistance Rp (Z = 5.06, P < 0.001) and capacitance CT (Z = 3.32, P < 0.001) of the blood exposed to magnetic field, by approximately 10.4% and 1.9%, respectively.

Regresion polinomial de la somatometria durante la pubertad en tres niveles socioeconomicos de Leon, Guanajuato. / Polynomial regression of somatometric data during puberty in 3 socioeconomic levels of Leon, Guanajuato

Se estudiaron 2,488 jovenes (1,380 varones y 1,108 mujeres) entre los 8 y los 18 anos y entre los 6 y los 16 anos de los sexos respectivos, obtenidos de tres tipos socioeconomicos escolares (escuelas privadas, oficiales urbanas y rurales). Se obtuvo la alla, el peso, la circunferencia del brazo, la circunferencia del muslo y el perimetro cefalico, asi como las costumbres alimentarias para la ingestion de carne, leche, huevo y frijoles. Se calcularon las tablas del crecimiento para cada parametro agrupando los datos en intervalos de 0,50 anos. Se efectuo regresion polinomial de los datos hasta el 6o. grado y en ella se observo claramente las diferencias en las curvas de regresion del crecimiento en cada parametro estudiado.Con base en la ecuacion polinomial, se calculo la velocidad del crecimiento y la edad de la velocidad maxima. Se encontro una instalacion mas temprana en los estrados socioeconomicos mas favorecidos para el peso corporal, la circunferencia del brazo y la circunferencia del muslo. La edad de instalacion del maximo crecimiento de la estatura de pie no mostro diferencia en los tres grupos estudiados